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产品说明/Specification Sheet
产品名称: |
Fibrinogen 纤维蛋白原(牛血) |
产品编号: |
CF5311-250mg |
规格: |
250mg |
价格: |
¥350 |
产品类别: |
生化试剂 |
CAS#: |
9001-32-5 |
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品牌: |
coolaber |
级别: |
BR Grade |
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分子式: |
N/A |
分子量: |
N/A |
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危险品: |
NO |
危险品系数: |
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储存条件: |
-20 °C |
说明书: |
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产品属性:
Description
Analysis Note |
Protein determined by biuret |
Physical form |
Contains ~10% sodium citrate and ~15% sodium chloride. |
Biochem/physiol Actions |
Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source. |
Properties
type |
Type I-S |
mol wt |
α-chain mol wt 63.5 kDa |
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β-chain mol wt 56 kDa |
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γ chain mol wt 47 kDa (about 4% carbohydrate content) |
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soluble dimer mol wt 340 kDa |
storage temp. |
−20°C |
别名: 纤维蛋白原;牛血纤维蛋白原;纤维蛋白原(牛血 Fibrinogen from human plasma
产品用途:生化研究。可用于链激酶(SK)、尿激酶(UK)、组织血纤溶酶原激活剂(tPA)、单链尿激酶型血纤溶酶原激活剂(SCUPA)等粗略效价(溶圈法)测定。
物理性质:白色粉末或疏松易碎块状物,略溶于水,溶解后呈无色、无臭澄清略带乳光的黏性液体,可有微量细小不溶蛋白存在。
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